PRESERVING AND RESTORING THE SKIN BARRIER IN DYSBIOTIC SKIN

Dysbiotic skin means that you have an imbalance in the different types of micro-organisms living in your skin. If there are too many of some types and not enough of others, they don’t work with you as they should, and they might work against you.

In particular, dysbiosis in the skin may have broad effects on its barrier function.

OxiProteomics offers advanced testing to demonstrate the efficacy of your products in protecting and strengthening this vital defense system.

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EXPLORE OUR INNOVATIVE TESTING

An ex vivo human skin model was developed to replicate barrier dysfunction induced by microbiota dysbiosis.

  • The Before image shows the damaging effects of S. aureus bacteria on the skin, associated to an unbalanced skin microbiome (microbiota dysbiosis).
  • The After image shows the recovery and benefit on the skin when the product is applied.

We can help you:

  • Model microbiome dysbiosis: Accurately assess how your product performs under challenging conditions.
  • Measure barrier function: Quantify the impact of your product on skin permeability and resilience.
  • Substantiate your claims: Provide scientific evidence to support your marketing messages.
BEFORE
AFTER

Showing the benefit of product on the skin barrier after exposure to S. aureus proteases.

SCIENTIFICALLY PROVEN RESULTS

  • Our microbiome dysbiosis testing services provide detailed insights into the interactions with the skin, empowering you to develop effective strategies to address early biological events and promote, maintain and restore functional healthy skin.

  • This model can be helpful to guide the development of active ingredients or formulations that:
    • Protect/preserve the skin barrier.
    • Help restore a healthy skin microbiome balance.
    • Address skin problems related to S. aureus and dysbiosis.
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A disrupted barrier allowed the penetration of a fluorescent probe (in yellow). The product effectively improved the skin barrier function upon application.

WHO WE ARE

OxiProteomics is a CRO specialized in biomarker assessment providing research services for skin- & hair-care dermo-cosmetics, food supplements, medical devices, and dermatology efficacy evaluation.

Spined-out from Sorbonne University in 2014, our uniqueness is a specific know-how on non-targeted & targeted proteomics approaches adapted to skin and hair evaluation. We support our clients on molecular target identification, target validation, efficacy testing, mechanistic studies, prediction of responders, and biomarkers discovery.

We also propose predictive pre-clinical skin models coupled with spatial proteomics analyses, based on the organ culture of human skin samples. We also able work with clinical samples to perform bio-analysis. We also provide mechanistic investigator-initiator trials with the analysis of biopsies and non-invasive samples.

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With our deep understanding of proteomics and the cosmetic industry, we can help you unlock the full potential of your research and bring innovative, high-performing products to market.