Scalp Discomfort - Oxiproteomics

PROVEN BENEFITS FOR SCALP DISCOMFORT CLAIMS

Scalp discomfort, characterized by itching, burning, or tightness, can significantly impact quality of life and is often a sign of an underlying scalp condition. This discomfort can stem from various factors, including dryness, inflammation, sensitivity to certain ingredients, or an imbalance in the scalp’s microbiome.

Today’s consumers are increasingly seeking products that not only address visible scalp issues but also provide relief from discomfort and promote long-term scalp health.

At OxiProteomics, we offer specialized assays to evaluate the efficacy of your scalp care products in alleviating scalp discomfort. Using ex-vivo human scalp models and precise biomarker analysis, we can demonstrate your product’s ability to reduce inflammation, restore the scalp barrier, and soothe irritation. Our scientific approach provides robust evidence to support your product claims, enhancing consumer trust and confidence in your brand’s ability to deliver effective solutions for scalp discomfort.

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ModeLs available

In-Vitro(2d and co-culture)/ex-vivo(scalp explant)/in-vivo(scalp biopsy & tape stripping)

Uv/ir/blue light/heat/outdoor & indoor pollution

Basal(No Stressor)

Typical Concerns

INFLAMMATION/ ITCHING/ IRRITATION/ DESQUAMATION/ DANDRUFF

EXPLORE OUR INNOVATIVE TESTING

These images illustrate the effect of microbiome imbalance on the expression of IL-31, a cytokine heavily implicated in scalp discomfort and itch

Without Product: Upon a condition pof microbiome imbalance, a significant increase in IL-31 expression is observed. The intense red fluorescence signifies an amplified inflammatory response. This heightened IL-31 level is directly associated with the sensation of itch and discomfort.

After (with Product): Shows the drop of IL-31 levels (red fluorescence) in a healthy scalp. The limited red fluorescence indicates a normal, balanced immune response.

BEFORE

AFTER

Showing the benefit of product on IL-31 levels.

SCIENTIFICALLY PROVEN RESULTS

Benefits for our customers:

Targeted relief: This visual evidence underscores the need for products that specifically target the inflammatory pathways activated by Malassezia, aiming to reduce IL-31 production and alleviate scalp discomfort.
Ingredient efficacy: The image can be used to assess the efficacy of ingredients that modulate immune responses and reduce inflammation, such as anti-inflammatory agents, prebiotics, and postbiotics.
Claim substantiation: Provides compelling scientific support for claims related to itch relief, scalp comfort, and the reduction of inflammatory responses.

OxiProteomics as a partner:

OxiProteomics’ expertise in scalp biology and advanced imaging techniques enables us to:

Quantify inflammatory markers: Accurately measure changes in IL-31 and other inflammatory mediators in response to different treatments.
Visualize cellular responses: Provide detailed insights into the complex interplay between Malassezia, the scalp microbiome, and the immune system.
Develop customized assays: Tailor experiments to address specific research questions and product development needs.

By partnering with OxiProteomics, companies can gain a deeper understanding of the mechanisms underlying scalp discomfort and develop targeted solutions that effectively address this widespread consumer concern.

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Noticeable reduction in IL-31 levels after application of product.

WHO WE ARE

OxiProteomics is a CRO specialized in biomarker assessment providing research services for skin- & hair-care dermo-cosmetics, food supplements, medical devices, and dermatology efficacy evaluation.

Spined-out from Sorbonne University in 2014, our uniqueness is a specific know-how on non-targeted & targeted proteomics approaches adapted to skin and hair evaluation.

We support our clients on molecular target identification, target validation, efficacy testing, mechanistic studies, prediction of responders, and biomarkers discovery. We also propose predictive pre-clinical skin models coupled with spatial proteomics analyses, based on the organ culture of human skin samples. We also able work with clinical samples to perform bio-analysis. We also provide mechanistic investigator-initiator trials with the analysis of biopsies and non-invasive samples.

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