HELPING TO PROTECT AND RESTORE DYSBIOTIC SKIN

The skin’s microbiome—a delicate ecosystem of beneficial microorganisms living on our skin—plays a vital role in maintaining skin health and barrier function. When balanced, these commensal microbes protect against external aggressors and support overall skin wellness.

However, certain conditions, such as atopic skin and dermatological disorders like psoriasis and acne vulgaris, are associated with opportunistic strains, such as S. aureus, overgrowing. These strains can release virulence factors that disrupt the skin barrier and worsen skin inflammation and damage.

At OxiProteomics, we offer cutting-edge assays to scientifically validate how your skincare products address the impacts of an unbalanced microbiome.

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EXPLORE OUR INNOVATIVE TESTING

Our exclusive LeakySkin™ Model simulates dysbiosis, providing a precise platform for evaluating the efficacy of skincare products in restoring skin functions and combating the detrimental impacts of microbiota dysbiosis.
This innovative model closely mimics the adverse effects of S. aureus virulence factors on the skin, allowing to prove how your product works to repair and protect the skin from the consequences of dysbiosis.

The “Before” image captures the skin model heavily compromised by S. aureus proteases, where brighter red/orange coloring that indicates extensive carbonylation (oxidation) damage—a marker of oxidative stress and premature aging.
The “After” image illustrates the skin’s remarkable recovery following product application, evidenced by significantly reduced carbonylation levels.

BEFORE
AFTER

The extensive skin carbonylation damage induced by microbiota dysbiosis, indicated by bright red/orange coloring, is visibly reduced following significant recovery post-product application.

SCIENTIFICALLY PROVEN RESULTS

Pre-, Pro-, and Post-Biotics are innovative skincare products. Using our Leaky Skin platform, you can explore their positive effects in preserving, defending, and repairing the skin from aggressions caused by microbiota dysbiosis.

The results provide robust scientific evidence that your product significantly mitigates the effects of microbiota dysbiosis, participating or enhancing the skin’s defense mechanisms and promoting a healthier, more resilient complexion. Your skincare solution can offer profound protective benefits, positioning it as an essential tool for maintaining skin health amid microbial imbalances.

Partner with OxiProteomics to leverage these compelling findings in your marketing strategy, reassuring consumers of your product’s proven efficacy and its foundation in advanced science.

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Noticeable decrease in carbonylation levels after application of product.

WHO WE ARE

OxiProteomics is a CRO specialized in biomarker assessment providing research services for skin- & hair-care dermo-cosmetics, food supplements, medical devices, and dermatology efficacy evaluation.

Spined-out from Sorbonne University in 2014, our uniqueness is a specific know-how on non-targeted & targeted proteomics approaches adapted to skin and hair evaluation. We support our clients on molecular target identification, target validation, efficacy testing, mechanistic studies, prediction of responders, and biomarkers discovery.

We also propose predictive pre-clinical skin models coupled with spatial proteomics analyses, based on the organ culture of human skin samples. We also able work with clinical samples to perform bio-analysis. We also provide mechanistic investigator-initiator trials with the analysis of biopsies and non-invasive samples.

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With our deep understanding of proteomics and the cosmetic industry, we can help you unlock the full potential of your research and bring innovative, high-performing products to market.