Hydration - Oxiproteomics

The MICROBIOTA DYSBIOSIS AND SKIN HYDRATION

Hydration plays a crucial role in skin health. Dysbiosis of the skin microbiota negatively affects the integrity of the skin barrier and its ability to protect against increased skin permeability. As a consequence, the skin becomes more vulnerable to environmental stressors that may penetrate deeper due to the loss of barrier function. Additionally, this increased permeability can lead to a loss of skin hydration. OxiProteomics offers advanced analysis to help you understand how your products improve or maintain skin hydration at the molecular level.

Models Available

3d in-vitro/ ex-vivo

Stressor Used

S. Aureus virulence factors

Typical Concerns

accelerated aging/ xerosis & Dry Skin/ Itching/ dermatoses / Atopic dermatitis

explore our innovative models

The exposure to virulence factors of S. aureus induces early biological events, such as barrier disruption and related consequences. By focusing on the interaction between microbiota dysbiosis and its effects on the skin, we can investigate how it impacts the biological skin barrier and related biomarkers of skin hydration, including Filaggrin and how a formulation can efficiently prevent, restore, or maintain healthy skin hydration. Filaggrin is a key structural protein involved in the barrier function and surface hydration of the skin, forming Natural Moisturizing Factors (NMF) that are essential for the skin’s ability to retain moisture.

“Before” image: Shows significantly decrease of Filaggrin detection, indicating barrier disruption associated to a loss of superficial hydration.
“After” image: Shows preserved Filaggrin levels upon product application, associated to intact skin barrier.

BEFORE

AFTER

Showing the benefit of the product in enhancing skin barrier function and preserving skin hydration, thanks to the stimulation of filaggrin (highlighted in bright colors).

scientifically proven results

The model mimics aspects of atopic dermatitis, where filaggrin deficiency and S. aureus colonization are common features.

Targeting filaggrin degradation or enhancing its function could be a potentially beneficial strategy to overcome hydration issues in the context of skin microbiota dysbiosis.

Visibly healthier barrier after application of product.

WHO WE ARE

OxiProteomics is a CRO specialized in biomarker assessment providing research services for skin- & hair-care dermo-cosmetics, food supplements, medical devices, and dermatology efficacy evaluation.

Spined-out from Sorbonne University in 2014, our uniqueness is a specific know-how on non-targeted & targeted proteomics approaches adapted to skin and hair evaluation. We support our clients on molecular target identification, target validation, efficacy testing, mechanistic studies, prediction of responders, and biomarkers discovery.

We also propose predictive pre-clinical skin models coupled with spatial proteomics analyses, based on the organ culture of human skin samples. We also able work with clinical samples to perform bio-analysis. We also provide mechanistic investigator-initiator trials with the analysis of biopsies and non-invasive samples.

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With our deep understanding of proteomics and the cosmetic industry, we can help you unlock the full potential of your research and bring innovative, high-performing products to market.