By using targeted and untargeted proteomics approaches, our scientific team provides solutions for efficacy validation, from screening up to clinical studies
Active ingredient screening
Screening of active ingredients or concentrations based on their biological effect on living cells, through semi-quantification of carbonylated proteins (Oxi-Proteome) by fluorimetry, allowing to select the best promising for in depth efficacy studies.
In situ vizualisation of molecular damage protection
Specific labelling and fluorescence imaging of carbonylated proteins (Oxi-Proteome) to evidence the protective effect of active ingredients or finished products on cells, on distinct anatomic compartments (Stratum corneum, epidermis and dermis), or upon Stratum corneum tape stripping.
Quantification of molecular damage protection
Efficacy score of protection of active ingredients or finished products based on the absolute quantification of carbonylated proteins (Oxi-Proteome) (normalization by total proteins), adapted for both : ex vivo and in vivo studies.
Evidencing protective mechanisms of action
Identification of skin proteins specifically protected through the quantification of protein oxidative rate variation upon stress or physiological condition to evidence the signature of protection of active ingredients or finished products.
In situ visualization of key biomarkers
High-resolution fluorescence imaging to further evidence the effect of active ingredients or finished products on key protein biomarkers involved in skin structure and function, on distinct anatomic compartments.
Evidencing mechanism of action and new biomarkers
Proved tool based on untargeted proteomics approaches for deep analyses to accelerate time to market of novel active ingredients by underlining their mechanisms of action under stress or physiological conditions and by discovering previously unknown biological targets (proteins) involved in skin function.
We offer added value to Expression proteomics studies by interpreting OMICS data focused on skin biology, in a precise and reliable way, ready to use: