Protein oxidative damage: a target for efficient dermo-cosmetic treatments

In addition to chronological ageing, the skin and hair are also damaged by environmental stressors (Indoor and Outdoor pollution, Chemical and Heat treatment) accelerating this process. Both chronological and environmental-induced ageing are caused by oxidative damage to our macromolecules, in particular to proteins, the main component of our skin and hair shaft.

Claims substantiation

Our scientific team provides solutions for efficacy validation from biological screening of new actives up to marketing claims of finished products:

Active screening

Carbonyl screen is a method allowing to test in situ the protective effect of several actives at different concentrations upon different type of stress (Blue light, UV-A, Pollution, oxidative stress) using in vitro models of skin cells.

This first approach adapted to high-throughput screening allows defining the most promising actives and their optimal concentration for further studies.

In situ vizualisation of molecular damage protection

Imaging approaches allows the visualization of the proteins protected from the oxidation by your product, on cells or skin layers (derm, epidermis, stratum corneum).

The tested products can be applied on biological models (cells or skin explants) subjected to different type of stress (Pollution, UV-A, Blue light).

Quantification of molecular damage protection

This service provides a reliable read-out parameter for the efficacy testing of actives and finished products. We will evaluate the capacity of your product to protect human skin from stress (Pollution, UV-A, Blue light) induced molecular damage (protein oxidation) by a total quantification of oxidized proteins with high sensitivity and reproducibility. You will benefit of quantitative analysis under the form of Efficacy score.

Your actives can be tested on the biological model of your choice (cells or skin explants).

Evidencing mechanisms of action

This service provides the identification of protected proteins allowing the quantification of the oxidative rate variation of specific proteins. It offers a deeper analysis suitable for further substantiation of scientific or marketing claims or biomarker discovery.

Claims substantiation

Product application

By using state-of-the art proteomics technologies we provide innovative efficacy tests based on the evaluation of hair biological structure (protein) protection.

In situ vizualisation of molecular damage protection

The imaging by epi-fluorescence allows the visualization of the proteins protected from the oxidation by your product on hair shafts.

Quantification of molecular damage protection

This service provides a reliable read-out parameter for the efficacy testing of actives and finished products. We will evaluate the capacity of your product to protect hair shafts from stress (Pollution, UV-A, Heat and Chemical treatment) induced molecular damage (protein oxidation) by a total quantification of oxidized proteins with high sensitivity and reproducibility. You will benefit of quantitative analysis under the form of Efficacy score.

Let’s talk

Our scientific team possesses expertise using in vitro and ex vivo models of human skin coupled with innovative analyses at the molecular level.  Working with our customers, we are able to develop and validate also customized projects.  

Because living models are used, we provide a functional read-out of compound activity, or produce results that are more biologically/physiologically relevant than in-tubo assays.

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