Scalp Barrier - Oxiproteomics

STRENGTHENING SCALP BARRIER

A healthy scalp promotes better anchorage for hair follicles, and a functional scalp barrier is crucial for maintaining them functional. This barrier defends against external aggressors like pollution and UV radiation, prevents moisture loss, and protects against irritation and inflammation, leading to dryness, itching, and a compromised scalp microbiome.

In today’s market, consumers increasingly seek products that support and maintain a strong scalp barrier.

At OxiProteomics, we provide comprehensive scientific validation of your scalp care products through our advanced testing platform. Utilizing ex-vivo human scalp models and precise biomarker analysis, we clearly demonstrate your product’s efficacy in strengthening the scalp barrier, improving hydration, reducing inflammation, and promoting a healthy microbiome. This enables you to make strong, scientifically-backed claims that resonate with consumers seeking optimal scalp health.

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ModeLs available

3D In-vitro / Ex-vivo (Scalp Explants)

Stressor / STIMULI

BASAL TREATMENTS/ UV/ blue light/ outdoor & indoor pollution/ MICROBIOME DYSBIOSIS

Typical Concerns

scalp balance/ IRRITATION / Dryness/ Protection against external aggressions

EXPLORE OUR INNOVATIVE TESTING

A key marker of scalp barrier function is TGM-1 (transglutaminase 1), an enzyme pivotal for strengthening the scalp’s skin barrier. TGM-1 is instrumental in the cross-linking of proteins that form the stratum corneum, thereby enhancing barrier integrity and moisture retention. By monitoring and optimizing TGM-1 activity, we can provide crucial insights into improving scalp health.

The accompanying images illustrate a comparison between untreated scalp explants and those treated with a barrier-enhancing compound. The yellow signal in the images represents TGM-1 detection on scalp sections, showcasing the products’s effectiveness in boosting the scalp’s barrier function and promoting healthier, more resilient scalp.

BEFORE

AFTER

Visibly healthy scalp upon product application through the evaluation of the increased of TGM-1 (in yellow), involved in critical role for strengthening the scalp’s skin barrier.

SCIENTIFICALLY PROVEN RESULTS

The assessment of barrier function biomarkers, such as TGM-1, offers solid scientific evidence to substantiate your product’s capability to fortify the scalp’s skin barrier and enhance moisture retention. This substantial data supports marketing claims and positions your product uniquely in a competitive hair care market.

Target Audience: Attract consumers looking for cutting-edge solutions for scalp health, barrier enhancement, and overall hair wellness.

Premium Positioning: Position your product as an advanced hair care innovation that not only supports scalp health but also addresses foundational concerns of scalp sensitivity and dryness.

Partner with OxiProteomics to gain definitive insights into your product’s performance and craft persuasive, science-based marketing strategies that resonate with your target audience and elevate your brand.

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Enhanced barrier function upon product application through the evaluation of TGM-1.

WHO WE ARE

OxiProteomics is a CRO specialized in biomarker assessment providing research services for skin- & hair-care dermo-cosmetics, food supplements, medical devices, and dermatology efficacy evaluation.

Spined-out from Sorbonne University in 2014, our uniqueness is a specific know-how on non-targeted & targeted proteomics approaches adapted to skin and hair evaluation. We support our clients on molecular target identification, target validation, efficacy testing, mechanistic studies, prediction of responders, and biomarkers discovery.

We also propose predictive pre-clinical skin models coupled with spatial proteomics analyses, based on the organ culture of human skin samples. We also able work with clinical samples to perform bio-analysis. We also provide mechanistic investigator-initiator trials with the analysis of biopsies and non-invasive samples.

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