proteome oxiproteomics

AUTOPHAGY ACTIVATION: A PATH TO YOUTHFUL SKIN 

Autophagy is involved in the skin’s natural recycling and repair process, playing a vital role in maintaining cellular health and promoting healthy longevity. 

In skin cells, efficient autophagy helps eliminate damaged proteins and organelles, reducing oxidative stress and promoting overall skin vitality. However, with age, the autophagy process slows down, leading to the accumulation of cellular waste and contributing to visible signs of aging such as dullness, fine lines, and loss of firmness.

At OxiProteomics, we provide advanced testing solutions to help cosmetic and skincare to validate products that stimulate autophagy. Our state-of-the-art assays quantify key autophagy markers, delivering scientific proof of your product’s ability to maintain a youthful and healthy skin.

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One key marker of autophagy is Lamp2a, a protein critical for the chaperone-mediated autophagy pathway. Lamp2a plays a pivotal role in maintaining cellular health by facilitating the degradation and recycling of damaged or misfolded proteins. By monitoring and modulating Lamp2a expression, we can gain valuable insights into enhancing autophagy.

The provided images show a comparison between untreated skin explants and those treated with a specific autophagy-activating compound. 

The green signal highlights the presence of Lamp2a, illustrating the compound’s ability to stimulate autophagy and promote longevity and healthier skin.

BEFORE
AFTER

Showing the products ability to stimulate autophagy.

SCIENTIFICALLY PROVEN RESULTS

 

The assessment of autophagy biomarkers, such as Lamp2a, provides robust scientific proof to validate your product’s ability to enhance cellular homeostasis and promote longevity. This powerful data strengthens marketing messages and differentiates your product in a competitive skincare market.

  • Target Audience: Attract consumers seeking advanced solutions for skin rejuvenation, longevity, and maintaining a healthy, youthful appearance, skin vitality.
  • Premium Positioning: Establish your product as a high-performance skincare innovation that directly stimulates autophagy, addressing the root cause of skin aging and deterioration.

Partner with OxiProteomics to uncover actionable insights into your product’s efficacy and create compelling, science-driven marketing strategies that resonate with your audience and elevate your brand.

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Noticeable increase of Lamp2a signal after product application.

WHO WE ARE

OxiProteomics is a CRO specialized in biomarker assessment providing research services for skin- & hair-care dermo-cosmetics, food supplements, medical devices, and dermatology efficacy evaluation.

Spined-out from Sorbonne University in 2014, our uniqueness is a specific know-how on non-targeted & targeted proteomics approaches adapted to skin and hair evaluation. We support our clients on molecular target identification, target validation, efficacy testing, mechanistic studies, prediction of responders, and biomarkers discovery.

We also propose predictive pre-clinical skin models coupled with spatial proteomics analyses, based on the organ culture of human skin samples. We also able work with clinical samples to perform bio-analysis. We also provide mechanistic investigator-initiator trials with the analysis of biopsies and non-invasive samples.

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With our deep understanding of proteomics and the cosmetic industry, we can help you unlock the full potential of your research and bring innovative, high-performing products to market.